Following a request for assessment in 2020 by the EU, the European Food Safety Authority (EFSA) assessed E171, particularly for its genotoxicity. In 2022, the agency deemed the food additive no longer safe for use.
The factory's commitment to quality is evident in its production process, which adheres to strict standards and regulations. By using advanced technology and techniques, CAS 13463-67-7 is able to produce titanium dioxide that meets the exact specifications of its customers. This ensures that the final product is of the highest quality and consistency, leading to better performance and results for the end-users.


The surge in demand for interior and exterior paints and use of plastic across various end-use industries drive the global Lithopone market. Lithopone white pigment is used in paints and coating systems that find applications in residential and industrial landscapes. Hence, as the construction & building sector flourishes, the demand for building and architectural materials such as paints and coatings will increase. This trend is conducive for the Lithopone market growth. In addition, white plastic materials are increasingly being used in consumer products. Developments in plastic forming technology is anticipated to indirectly boost plastic production, thus, increasing the demand for white pigments during the forecast period.
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Titanium dioxide is a naturally-occurring mineral found in the earth’s crust. Because of its white color, opaqueness, and ability to refract light, the ingredient is often used as a pigment, brightener, and opacifier, which is an ingredient that makes a formulation more opaque. Titanium dioxide is also a UV filter and so is an effective active ingredient in sunscreens. It’s often used in cosmetic loose and pressed powders, especially “mineral powder” cosmetics, in addition to other cosmetics, lotions, toothpaste, and soap.
For the production of titanium dioxide, the raw material of coatings, China coating Industry Association visited the production enterprises of titanium dioxide. During the visit, we found that Hebei Caixin Material Technology Co., LTD. (hereinafter referred to as Caiqing Technology) has done a lot of work in creating a green ecological industry in titanium dioxide production, and has achieved outstanding results.
Lithopone, an alternative to titanium dioxide
A study published in the Journal of Agricultural and Food Chemistry in 2019 sought to examine the effects of titanium dioxide on intestinal inflammation. Researchers did this by feeding rats titanium dioxide nanoparticles and found that, after the course of two to three months, the animals had lower body weights and induced intestinal inflammation. The researchers also found the nanoparticles altered gut microbiota composition and aggravated chronic colitis. The rats also experienced reduced populations of CD4+T cells (which are cells that help organize immune responses by prompting other immune cells to fight infection), regulatory T cells, and white blood cells in mesenteric lymph nodes. The researchers wrote: “Dietary TiO2 nanoparticles could interfere with the balance of the immune system and dynamic of gut microbiome, which may result in low-grade intestinal inflammation and aggravated immunological response to external stimulus, thus introducing potential health risk.”

However, they did find that minor levels of 0.01% were absorbed by immune cells — known as gut-associated lymphoid tissue — and may be delivered to other organs. Currently, it’s unknown how this may affect human health (17Trusted Source).