propargyl alcohol cas

Propargyl Alcohol A Comprehensive Overview

Propargyl alcohol, known chemically as 3-buten-1-ol, is a compound that has garnered interest in various fields, particularly in organic chemistry and industrial applications. With the CAS Registry Number 107-18-6, propargyl alcohol presents itself as a colorless liquid characterized by a distinct odor reminiscent of that of alcohols and alkenes. Its unique chemical structure, consisting of an alkyne group attached to a hydroxyl (OH) functional group, equips it with a range of intriguing properties and reactivity patterns.

Propargyl alcohol is denoted by the molecular formula C3H4O, indicating it is composed of three carbon atoms, four hydrogen atoms, and one oxygen atom. The structure contains both an alkyne and an alcohol functional group, making it an interesting compound for various chemical reactions. The presence of the alkyne group contributes to its reactivity, allowing it to engage in a plethora of addition reactions, while the hydroxyl group provides typical alcohol function characteristics.

The compound features a boiling point of 135°C and a melting point at approximately -12°C, demonstrating its liquid state at room temperature. It is moderately soluble in water, enhancing its appeal in aqueous reactions and applications. Propargyl alcohol is flammable and should be handled with care, adhering to appropriate safety guidelines in laboratory and industrial settings.

Applications and Uses

The versatility of propargyl alcohol allows it to serve in multiple domains. One of its most prominent roles is as an intermediate in the synthesis of various organic compounds. It is employed in the production of propargyl derivatives, which can be utilized in pharmaceuticals, agrochemicals, and fine chemicals. Its alkyne functional group provides a reactive site for further chemical modifications, allowing synthetic chemists to create a diverse array of products.

Furthermore, propargyl alcohol acts as a building block in the synthesis of bioactive compounds. Its derivatives have been explored for potential applications in drug development, particularly in creating novel therapeutic agents. The presence of the alkyne group can facilitate reactions such as cycloadditions, which might lead to the generation of complex molecular architectures valuable in medicinal chemistry.

In addition to its use in synthesis, propargyl alcohol finds its application in the production of polymers. It can serve as a crosslinking agent in the formulation of polymers, enhancing their properties and performance. The resulting materials can be utilized in coatings, adhesives, and sealants, showcasing the material's broad industrial relevance.

Safety and Handling

As with many chemicals, safety precautions are essential when handling propargyl alcohol. It is flammable and poses a risk of fire if not stored and utilized correctly. Users should ensure that it is kept in well-ventilated areas away from sources of ignition. Standard personal protective equipment (PPE) such as gloves, goggles, and lab coats should be worn to mitigate exposure risks. Moreover, it’s crucial to refer to the Safety Data Sheet (SDS) for detailed information regarding handling, storage, and exposure measures.

Conclusion

In summary, propargyl alcohol is a fascinating compound that plays a significant role in both academic research and industrial applications. Its unique structure and reactivity properties make it a valuable intermediate in organic synthesis, offering avenues for creating diverse compounds with potential pharmaceutical and industrial uses. As research continues to unveil new applications and derivatives of propargyl alcohol, its significance in chemical processes will likely expand, solidifying its place in the realm of organic chemistry and beyond. For researchers and professionals engaged in chemistry, propargyl alcohol remains a compound of considerable interest and importance.